TIGER-2, the second Phase 3 clinical trial with denufosol for the treatment of CF, was a 48-week, placebo-controlled, double-blind, randomized trial comparing 60 mg of denufosol to placebo, administered three times daily by jet nebulizer in 466 patients with mild cystic fibrosis lung disease (baseline FEV1 greater-than or equal to 75% and less-than or equal to 110% of predicted normal).Every student should have access to a mentorship experience as a tool in their career development. The placebo-controlled portion was a double-blind, randomized trial comparing 60 mg of denufosol to placebo, administered three times daily by jet nebulizer, in 352 patients with mild cystic fibrosis lung disease (baseline FEV1 greater-than or equal to 75% of predicted normal). TIGER-1, the first Phase 3 trial with denufosol for the treatment of CF, included a 24-week placebo-controlled portion, followed by a 24-week open-label safety extension. Inspire will be communicating with participating clinical trial sites on the next steps for the DEFY trial in the near future.Ībout the Denufosol Tetrasodium Clinical Program Based on the lack of meaningful benefit observed in TIGER-2, Inspire will be recommending that patients in the DEFY trial discontinue treatment with denufosol. Patients that completed the TIGER-2 trial were eligible to enroll in a separate three-year open-label trial of denufosol called DEFY. antibiotics for at least one respiratory sign or symptom, was similar in both treatment arms (21% for denufosol, 26% for placebo). The incidence of pulmonary exacerbations, as defined by treatment with I.V. The incidence of AEs and serious adverse events in the denufosol group was comparable to the placebo group. The most common AE was cough, which was similar in both treatment arms. Six percent of patients in both g roups withdrew from the trial due to adverse events (AEs). Patient retention rates were similar between treatment groups with approximately 82% completing the trial (82% for denufosol, 83% for placebo). antibiotics for at least one respiratory sign or symptom (p=0.132). Time to first pulmonary exacerbation, as defined by treatment with I.V.Change from baseline in FEF25%-75% (Forced Expiratory Flow) at the Week 48 Endpoint, a measure of small airways function (-0.034 L/sec for denufosol, -0.018 L/sec for placebo p=0.728) and.Rate of change in percent predicted FEV1 over 48 weeks, a measure of lung function adjusted for a patient’s predicted normal based on height, weight and gender (-2.30% for denufosol and -3.02% for placebo p=0.410). There were no statistically significant differences between denufosol and placebo for three key secondary endpoints, which were: (82%), Australia and New Zealand (11%) and Canada (6%). We want to thank the investigators, cystic fibrosis patients and caregivers for their involvement in this trial.”įor the 466 patients randomized in TIGER-2, the treatment groups were balanced with respect to demographic and background characteristics: the mean age was 15.1 years, the mean lung function was 89.7% of the predicted normal value of FEV1 and the use of concomitant medications including inhaled antibiotics, dornase alfa (PULMOZYME(R)), and oral macrolide antibiotics was similar between the treatment groups. The analysis of the primary endpoint, key secondary endpoints and select subgroup populations in TIGER-2 indicates an absence of meaningful treatment benefit in this patient population. Johnson, M.D., Executive Vice President of Research and Development and Chief Medical Officer, stated, “We believe that the TIGER-2 trial was designed and executed appropriately and was sufficient to provide data on the efficacy of denufosol at 48 weeks. Meanwhile, we will continue to focus on our ophthalmology business.”Ĭharles A. We expect to provide a detailed corporate update by mid-February. We will conduct a thorough analysis of the data to fully understand the results from this trial and the impact on any future development of denufosol and on the Company going forward. Patients receiving denufosol in the 466-patient, double-blind, placebo-controlled clinical trial had an improvement of 40 mL, compared to 32 mL for the patients receiving placebo (p=0.742).Īdrian Adams, President and CEO of Inspire, stated, “These TIGER-2 results were disappointing and unexpected given the treatment effect observed in the TIGER-1 trial. The trial did not achieve statistical significance for its primary efficacy endpoint, which was change from baseline in FEV1 (Forced Expiratory Volume in One Second) at the Week 48 Endpoint (48 weeks or last observation carried forward). announced today the top-line results from its second Phase 3 clinical trial, TIGER-2, with denufosol tetrasodium for the treatment of cystic fibrosis.
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It is possible that a Priority Mail package subject to dimensional-weight pricing due to its size and destination address may cost more to mail than an item of the same size/weight shipped to an international destination using Priority Mail International service.Because the size of the box, rather than just the weight, affects postage prices, remind customers to practice “right-size” shipping (see page 10 in this issue of the Postal Bulletin) and select mailing containers that are close in size to the item(s) being shipped.The balloon rate is limited to local and Zones 1–4 only, to reflect the costs of handling and transporting large parcels via surface transportation.These packages are charged the 20-pound balloon rate. Complimentary Priority Mail packaging - which is available for order online, by telephone (80), and at Post Offices - is never subject to dimensional-weight pricing.īalloon-rate pricing applies to Priority Mail packages (addressed for delivery to local and Zones 1–4 only) measuring more than 84 inches in combined length and girth and weighing less than 20 pounds.No Priority Mail item will ever be subject to both dimensional-weight and balloon-rate pricing.See the article titled “Holiday Mailing Tips and Reminders” on page 10 in this issue of the Postal Bulletin. Remind customers to practice “right-size shipping” when preparing their items for mailing.Other commercial carriers use this standard to determine prices for packages shipped by air. It is based on a standard issued by the International Air Transport Associations (IATA). Dimensional-weight pricing aligns our Priority Mail prices with the costs we incur for shipping these items by air. If a large package is relatively light and addressed for delivery to Zones 5–8, it could be charged as a heavier-weight item. It converts the cubic size of a mailpiece into a dimensional weight. Priority Mail Dimensional-Weight Pricingĭimensional-weight pricing is based on the cubic capacity of a package rather than on weight. The Priority Mail Flat-Rate Envelope is priced at $4.60 - the same as the (unzoned) 1-pound rate.Īn overview of Priority Mail dimensional-weight and balloon-rate pricing is provided below to help you understand the changes and be prepared to discuss them with customers. The Priority Mail Flat-Rate Box is priced at $8.95, regardless of weight, contents, or distance traveled.The maximum size for Priority Mail items is 108 inches in combined length and girth (the length of the longest side, plus the distance around its thickest part).The weight limit for Priority Mail items is 70 lbs.Priority Mail items are First-Class Mail items weighing more than 13 ounces and, at the mailer’s option, any other material (including First-Class Mail items) weighing 13 ounces or less. New Hope Auto Sales has the best used car prices the PA area has to offer. We carry a great selection of used cars as well as scooters, vans, trucks, SUV's, crossovers, motorcycles, utility body vehicles, and more! Call us today or apply online for your car financing. We are an easy drive if you live in the Philadelphia PA region, also other parts of PA, NJ, MD, NY, and CT areas. We are also a power seller on Ebay and have excellent feed back. 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Usually only used by Surface Warfare Officers.īLUEJACKET – Navy enlisted member below the grade of CPO.īOATSWAIN – pronounced “bosun,” refers to the mate, warrant officer, or petty officer in charge of boats, rigging, and ground tackle aboard a ship.īRIDGE – platform or area from which ship is steered, navigated, and conned usually located in the forward part of a ship.īROW – large gangplank leading from a ship to a pier, wharf, or float usually equipped with handrails.īULKHEAD – one of the upright, crosswise partitions dividing a ship into compartments.ĬAPTAIN – rank, or commanding officer of a ship or squadron.ĬATAPULT – a shipboard mechanism for launching aircraft.ĬHAIN OF COMMAND – the military’s management concept.ĬHAPLAIN – the military men and women of the cloth who nurture the spiritual well-being of service members.ĬLASSIFIED MATTER – information or material of aid to a possible enemy, if improperly divulged. It means “I have heard the order I understand it I will carry it out.”īARNACLE – a small marine animal that attaches itself to hulls and pilings.īELAY – to cancel an order stop firmly secure a line.īERTH – space assigned ship for anchoring or mooring.īERTHING – where Sailors sleep onboard ship.īILLET – an allotted sleeping space an individual’s position in the ship’s organization.īLACK SHOE – an officer who is not an aviator the latter is a brown shoe. A designated area of a port or harbor.ĪNCHORS AWEIGH – said of the anchor when just clear of the bottom.ĪYE-AYE – a term used to acknowledge receipt of a command or order from a senior. The smallest Navy anchors can be lifted by one person anchors used by an aircraft carrier can each weigh up to 30 tons.ĪNCHORAGE – a suitable place for a ship to anchor. This must be repaid.ĪFT – toward the stern opposite of forward.ĪLLOTMENT – assignment of part of military pay directly to a person or bank.ĪLONGSIDE – beside a pier, wharf, or ship.ĪNCHOR – the hook used at the end of a chain and dropped to the sea bottom to hold a ship in one particular place. Close aboard near a ship.ĪDVANCE PAY – an advance on your base pay for a move. Ĭlick here to scroll to Acronyms NAVY TERMS A B C D E F G H I J K L M N O P Q R S T U V W X Y Z AĪBOARD – on or in a ship. NAVY TERMS & ACRONYMS To download a PDF copy of this document, CLICK HERE. The Lone Sailor Table - Prisoner of War/Missing in Action (POW/MIA) Information and Assistance (website links) All information reflects our best knowledge at the time of publication. Also, the web addresses included change frequently. Naval Services FamilyLine does not officially endorse any of the organizations in the following documents that are non-federal entities. This section is provided for information dissemination purposes only. The image is taken from a video uploaded to the church's Facebook page. Jacob Reaume, pastor at Trinity Bible Chapel in Waterloo, Ont., speaks at a 2021 event in Waterloo Town Square. This movement is now increasingly involved in electoral politics, advocating for conservative social and political policies based on literal interpretations of the Bible. Trinity Bible is one of the most prominent churches in a fundamentalist Christian movement that has gained momentum in Canada, initially by challenging pandemic public health restrictions. He then used a slur to refer to trans people. "If you're going to live a lie to the point where you're willing to mutilate your own body, it's going to send you into dark despair," Reaume said. Much of the sermon, delivered last December, was devoted to a trans student at a Christian university in nearby Hamilton who had died by suicide a few weeks earlier. "A Christless existence leads to the dark, hopeless abyss of death," he told around 200 people at Trinity Bible Chapel, an evangelical church on the outskirts of the city. On a recent Sunday morning in Waterloo, Ont., pastor Jacob Reaume gripped a lectern and issued a warning to his congregation. Warning: This story contains anti-trans comments and deals with suicide. Front Burner 33:52 Inside the fundamentalist Christian movement that wants to remake Canadian politics The following sections don't end even after the Contract ends: 3 (Representations) 6 (Confidential Information) 7 (Limitation of Liability) 8 (Indemnity) and 9 (General). If either party ends this Contract before the Contract automatically ends, the Client will pay the Contractor for the work done up until when the Contract ends. The Coach must immediately stop working as soon as it receives this notice unless the notice says otherwise. The party that is ending the Contract must provide notice by taking the steps explained in Section 9.4. The Contract officially ends once that time has passed. Either party may end this Contract for any reason by sending an email or letter to the other party, informing the recipient that the sender is ending the Contract and that the Contract will end in 7 days. This Contract is ongoing until it expires or the work is completed. If the Client provides the Coach with material to incorporate into the work product, the Client promises that this material does not infringe on someone else's intellectual property rights. The Coach promises that its work product does not and will not infringe on someone else's intellectual property rights, that the Coach has the right to let the Client use the background IP, and that this Contract does not and will not violate any contract that the Coach has entered into or will enter into with someone else.ģ.7 Client-Supplied Material Does Not Infringe. and foreign laws and regulations.ģ.5 Work Product Does Not Infringe. The Coach promises that the manner it does this job, its work product, and any background IP it uses comply with applicable U.S. If the Coach uses employees or subcontractors, the Coach also promises that these employees and subcontractors have signed contracts with the Coach giving the Coach any rights that the employees or subcontractors have related to the Coach's background IP and work product.ģ.4 Coach Will Comply With Laws. The Coach promises that it owns the work product, that the Coach is able to give the work product to the Client, and that no other party will claim that it owns the work product. Each party promises to the other party that it has the authority to enter into this Contract and to perform all of its obligations under this Contract.ģ.3 Coach Has Right To Give Client Work Product. This section contains important promises between the parties.ģ.2 Authority To Sign. The Client is responsible for implementing the insights and techniques learned from the Coach.ģ.1 Overview. The Client acknowledges and agrees that coaching is a comprehensive process that may explore different areas of the Client's life, including work, finances, health, and relationships. The Coach agrees to maintain the ethics and standards of behavior established by the International Coaching Federation (ICF). Both the Client and Coach must uphold their obligations for the relationship to be successful. A coaching relationship is a partnership between two or more individuals or entities, like a teacher-student or coach-athlete relationship. The Coach will not be available by telephone, or email in between scheduled sessions. Payment after that date will incur a late fee of 1.0% per month on the outstanding amount.ġ.6 Support. The Client agrees to pay the amount owed within 15 days of receiving the invoice. The Coach will invoice the Client in accordance with the milestones in Section 1.3. Expenses do not need to be pre-approved by the Client.ġ.5 Invoices. The Client will reimburse the Coach's expenses. Of this, the Client will pay the Coach $500.00 (USD) before work begins.ġ.4 Expenses. The Client will pay the Coach an hourly rate of $150. The Coach and Client will meet by video conference, 4 days per month for 2 hours.ġ.3 Payment. This Contract can be ended by either Client or Coach at any time, pursuant to the terms of Section 4, Term and Termination. The Coach will begin work on Februand will continue until the work is completed. The Client is hiring the Coach to develop a coaching relationship between the Client and Coach in order to cultivate the Client's personal, professional, or business goals and create a plan to achieve those goals through stimulating and creative interactions with the ultimate result of maximizing the Client's personal or professional potential.ġ.2 Schedule. This Contract is between Client (the "Client") and Acme LLC, a California limited liability company (the "Coach").ġ.1 Project. The URL log has a dest_name field with the FQDN and the Traffic log has a bytes_out field, so we need to correlate them to know how many bytes went out for each FQDN. In other words the last technique is the most efficient for Splunk, but the hardest for a human to read.Įach example will correlate traffic logs and url logs to determine how many bytes have been transferred between each FQDN in the time period. They are listed here in order of increasing search complexity and decreasing time cost. Correlation techniquesĮach of these techniques can be used to perform the same correlation, however, each has a different performance profile. This page includes a few common examples which you can use as a starting point to build your own correlations. In fact, Palo Alto Networks Next-generation Firewall logs often need to be correlated together, such as joining traffic logs with threat logs. I'm leaning towards the latter.A common use of Splunk is to correlate different kinds of logs together. Or I don't understand how this command works at all. So either I'm just that good at writing transaction commands. With this, you should have the info to write that report you wanted." And each receipt is organized by timestamp. Instead of saying, "Hey I broke these events into multiple receipts showing when the tunnel went down and when it came back up again. See these list of files, based on this 1 line I want them grouped this way."Īnd yet somehow Transaction turned around and said, "Oh! Okay, here you go." So my second question is, "How did transaction just 'know' to group like events together?"īecause, even with the correct options and constraints, I can very easily see a scenario where transaction says, "Hey I took the Columbus Ohio firewall logs and grouped all the events into 1 long receipt. But I never told Transaction, "Hey buddy. I manually checked the pre and post transaction command. Transactions appears to look at the list of events and say 'these events belong together based on that 1 search'. But to add insult to injury when I type this: 'transaction device_name startswith=tunnel-down endswith=tunnel-up' it just works as expected. I get that if I type just: 'transaction device_name' this is what will happen - 1 long receipt with every transaction on it. But if I look at what I've typed up above my first question is, "Whoa! Why doesn't transaction grab all the events and put them into 1 long receipt?" To start - I understand that Transaction will group sets of data based on the criteria you specify. I fully understand the logic and the decision making behind it. | transaction device_name startswith=tunnel-up endswith=tunnel-down Sourcetype="cisco:firewall" index=firewall (event_id="tunnel-up" OR event_id="tunnel-down") | transaction device_name startswith=tunnel-down endswith=tunnel-up So that when something like this comes up: sourcetype="cisco:firewall" index=firewall (event_id="tunnel-up" OR event_id="tunnel-down") No, I'm not going to take Transaction out on a date but I'd like to get to know it and learn what makes it tick. But after using Transaction i've started going, "Whoa! This is incredibly useful." 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